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The expression of the antioxidant enzyme SOD2 was reported to be inversely correlated with maternal body mass index (BMI), suggesting a potential compromise in antioxidant defenses as BMI increases, which may contribute to an elevated production of ROS in the placenta [48]

Many mutational and structural studies have been carried out on the mu and alpha classes of GST to elucidate the reaction mechanism, whereas knowledge about the pi class is still limited

These apparently opposing effects highlight that the impact of GSH-linked thiol modifications on pyroptosis is highly node-specific and should not be viewed as uniformly anti-inflammatory

Phe35, Val57, Phe92, Tyr96, His168, and Phe170 for Liproxstatin-1